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Mishra, Mithilesh N.
- Expression of Perlecan (Heparan Sulphate Proteoglycan) in Oral Squamous Cell Carcinoma
Authors
1 Department of Oral Pathology, KLE VK Institute of Dental Sciences, Belgaum, IN
2 Department of Oral Pathology, ITS Dental College & Hospital, Noida, IN
3 Department of Pathology, JN Medical College, Belgaum, IN
4 Department of Public Health Dentistry, KLE VK Institute of Dental Sciences, Belgaum, IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 1 (2012), Pagination: 185-188Abstract
Background
Perlecan is a basement membrane heparan sulfate proteoglycan. It plays a vital role in cell- cell adhesion, cell-matrix adhesion and is associated with several growth factors. Recently its role has been found in many pathological and physiological conditions. Aim of this study was to understand the immunolocalisation of perlecan in normal mucosa and oral squamous cell carcinoma and also to derive a correlation between perlecan expression and various grades of carcinoma.
Method
A total of thirty tissue blocks comprising of ten normal mucosa and twenty oral squamous cell carcinoma were included in the study. They were examined for the presence of perlecan protein core by immunohistochemistry using monoclonal antibody (Anti-Basement Membrane-type heparan sulfate proteoglycan core protein. Specificity: Mouse monoclonal anti human Perlecan Clone No: 85-9). Interpretation of staining was done and the observations statisticaly analysed by Fisher exact tests to evaluate the expression of perlecan within and around the tumor islands.
Results
In normal epithelium perlecan expression was limited to basal layer. In oral squamous cell carcinoma, perlecan was present in surface epithelium, stroma as well as tumor islands. Perlecan expression within tumor islands became scarce with the higher grades of carcinoma.
Conclusions
It was deduced from the results that with the increase in degree of carcinoma; more heparanase enzyme acts on perlecan and from the breakdown of perlecan; fibroblast growth factor, transforming growth factor-β and other growth factors are released. All these factors are known to promote tumor growth.
Keywords
Perlecan, Immunohistochemistry, Heparan Sulphate Proteoglycan, Oral Cancer, Growth Factors, Squamous Cell CarcinomaReferences
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- Effectiveness of Superbrain Asana on the Academic Performance in Dental Students — An Interventional Study
Authors
1 Department of Oral Pathology and Microbiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore - 570015, Karnataka, IN
2 Yoga Prana Vidya (YPV), Sri Ramana Trust, Mysore Yoga Vidya Pranic Healers Association (MYPHA), Mysore - 570022, Karnataka, IN
3 Department of Oral & Maxillofacial Pathology, School of Dental Sciences, Sharda University, Uttar Pradesh - 201308, IN
Source
Journal of Natural Remedies, Vol 21, No 4 (2021), Pagination: 291-295Abstract
Superbrain asana (SBA) is an ancient yogic exercise which is claimed to boost holistic well-being. It is established on the principles of subtle energy movement in the body and ear acupuncture. Proponents assert that this exercise improves cognition and academic performance. Our study aimed at assessing the effectiveness of SBA on the academic performance in dental students by comparison of the pre-intervention and post-intervention test scores. This interventional research had a pretest – posttest design and was conducted on 99 dental undergraduate students. SBA exercise was implemented for three months for six days in a week. Pre and post-intervention tests with multiple choice questions were administrated to the students without giving any prior intimation. The test scores were compared and the observations were subjected to statistical analysis. The data collected were analysed with the Wilcoxon signed-rank test of significance. It was found that there was a statistically significant increase in the median test scores after the intervention (p-value <0.001).With our study, we conclude that Superbrain asana intervention is highly effective in improving the academic performance of the dental students and it can be successfully incorporated into the professional education curriculum.Keywords
Academic Performance, Dental Students, Holistic Development, Superbrain Asana, Superbrain Yoga.References
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